Protein Mediators & Strategies for Inhibition
Neuronal Cell Death Induced by Ischemic and Hemorrhagic Strokes Commonly known as cerebral vascular events, strokes are a significant source of morbidity and mortality worldwide. Ischemic strokes account for approximately 80% of all strokes and are caused by obstructed arteries that deprive the brain of oxygen and other nutrients. In contrast, hemorrhagic strokes stem from ruptured blood vessels that increase intracranial pressure and reduce blood flow to the surrounding tissue. While the mechanisms of pathology differ between ischemic and hemorrhagic strokes, both induce neuronal cell death. 1,2 Depending on the area of the brain affected, neuronal death can either be fatal or can impair speech, vision, or other sensorimotor functions.